Article
G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.
PloS one - 1 Jan 2013
Müller Anne, Kleinau Gunnar, Piechowski Carolin L, Müller Timo D, Finan Brian, Pratzka Juliane, Grüters Annette, Krude Heiko, Tschöp Matthias, Biebermann Heike
Abstract excerpt
The G-protein coupled receptor 83 (GPR83) is an orphan G-protein coupled receptor for which the natural ligand(s) and signaling pathway(s) remain to be identified. Previous studies suggest a role of GPR83 in the regulation of thermogenesis and the control of circulating adiponectin. The aim of this study was to gain insights into the molecular underpinnings underlying GPR83 signaling. In particular, we aimed to...
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