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Article

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders.

British journal of pharmacology - 1 Mar 2014

Leach K, Sexton P M, Christopoulos A, Conigrave A D

Abstract excerpt

The human calcium-sensing receptor (CaSR) is widely expressed in the body, where its activity is regulated by multiple orthosteric and endogenous allosteric ligands. Each ligand stabilizes a unique subset of conformational states, which enables the CaSR to couple to distinct intracellular signalling pathways depending on the extracellular milieu in which it is bathed. Differential signalling arising from distinct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24111791
DOI: 10.1111/bph.12420
PMCID: PMC3952794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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