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Discovery and pharmacological characterization of nanobodies acting as potent positive allosteric modulators of the calcium-sensing receptor

2024-07-08

Abstract excerpt

The calcium-sensing receptor (CaSR) is responsible for sustaining a stable blood calcium concentration. Consequently, genetic and acquired changes in this G protein-coupled receptor can give rise to various calcium homeostasis disorders. Synthetic positive allosteric modulators targeting CaSR are currently used to treat hypercalcemia, but their usage is highly limited due to the high risk of severe hypocalcemia an...

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Literature Corpus work
b0e8a1d6-9dfa-5be8-843b-b6a6e30ddf18
DOI
10.1101/2024.07.08.602375
Open publication

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Discovery and pharmacological characterization of nanobodies acting as potent positive allosteric modulators of the calcium-sensing receptorDOI 10.1101/2024.07.08.602375
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