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Article

A high throughput screening assay system for the identification of small molecule inhibitors of gsp.

PloS one - 1 Jan 2014

Bhattacharyya Nisan, Hu Xin, Chen Catherine Z, Mathews Griner Lesley A, Zheng Wei, Inglese James, Austin Christopher P, Marugan Juan J, Southall Noel, Neumann Susanne, Northup John K, Ferrer Marc, Collins Michael T

Abstract excerpt

Mis-sense mutations in the α-subunit of the G-protein, Gsα, cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these mutations is constitutively active Gsα and increased levels of cAMP. The aim of this study was to develop an assay system that would allow the identification of small molecule inhibitors specific for the mutant Gsα protein, the so-called gsp oncogene. Commercially...

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Identifiers

PMID: 24667240
DOI: 10.1371/journal.pone.0090766
PMCID: PMC3965391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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