Article
Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes.
Leukemia - 1 Mar 2020
Montalban-Bravo Guillermo, Class Caleb A, Ganan-Gomez Irene, Kanagal-Shamanna Rashmi, Sasaki Koji, Richard-Carpentier Guillaume, Naqvi Kiran, Wei Yue, Yang Hui, Soltysiak Kelly A, Chien Kelly, Bueso-Ramos Carlos, Do Kim-Anh, Kantarjian Hagop, Garcia-Manero Guillermo
Abstract excerpt
Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and cytopenias due to uncontrolled programmed cell death. The presence of pro-inflammatory cytokines and constitutive activation of innate immunity signals in MDS cells suggest inflammatory cell death, such as necroptosis, may be responsible for disease phenotype. We evaluated 64 bone marrow samples from 55 patients with MDS or chronic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.