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Inflammasomes—New Contributors to Blood Diseases

23 Jul 2022

Abstract excerpt

Inflammasomes are intracellular multimeric complexes that cleave the precursors of the IL-1 family of cytokines and various proteins, found predominantly in cells of hematopoietic origin. They consist of pattern-recognition receptors, adaptor domains, and the enzymatic caspase-1 domain. Inflammasomes become activated upon stimulation by various exogenous and endogenous agents, subsequently promoting and enhancing...

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PMID: 35897704
DOI: 10.3390/ijms23158129

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