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Article

Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes.

JCI insight - 8 Aug 2022

McLemore Amy F, Hou Hsin-An, Meyer Benjamin S, Lam Nghi B, Ward Grace A, Aldrich Amy L, Rodrigues Matthew A, Vedder Alexis, Zhang Ling, Padron Eric, Vincelette Nicole D, Sallman David A, Abdel-Wahab Omar, List Alan F, McGraw Kathy L

Abstract excerpt

NLRP3 inflammasome and IFN-stimulated gene (ISG) induction are key biological drivers of ineffective hematopoiesis and inflammation in myelodysplastic syndromes (MDSs). Gene mutations involving mRNA splicing and epigenetic regulatory pathways induce inflammasome activation and myeloid lineage skewing in MDSs through undefined mechanisms. Using immortalized murine hematopoietic stem and progenitor cells harboring...

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Identifiers

PMID: 35788117
DOI: 10.1172/jci.insight.159430
PMCID: PMC9462508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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