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Article

Role of the pH in state-dependent blockade of hERG currents.

Scientific reports - 12 Oct 2016

Wang Yibo, Guo Jiqing, Perissinotti Laura L, Lees-Miller James, Teng Guoqi, Durdagi Serdar, Duff Henry J, Noskov Sergei Yu

Abstract excerpt

Mutations that reduce inactivation of the voltage-gated Kv11.1 potassium channel (hERG) reduce binding for a number of blockers. State specific block of the inactivated state of hERG block may increase risks of drug-induced Torsade de pointes. In this study, molecular simulations of dofetilide binding to the previously developed and experimentally validated models of the hERG channel in open and open-inactivated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27731415
DOI: 10.1038/srep32536
PMCID: PMC5059635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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