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DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation

11 Oct 2016

Abstract excerpt

Stem cells in adult tissues are constantly exposed to genotoxic stress and also accumulate DNA damage with age. However, it remains largely unknown how DNA damage affects both stem cell self-renewal and differentiation. In this study, we show that DNA damage retards germline stem cell (GSC) self-renewal and progeny differentiation in a Lok kinase-dependent manner in the Drosophila ovary. Both heatshock-inducible...

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PMID: 27729408
DOI: 10.1242/dev.141069

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