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Article

p53 is required for female germline stem cell maintenance in P-element hybrid dysgenesis.

Developmental biology - 15 Feb 2018

Tasnim Sadia, Kelleher Erin S

Abstract excerpt

Hybrid dysgenesis is a sterility syndrome resulting from the mobilization of certain transposable elements in the Drosophila germline. Particularly extreme is the hybrid dysgenesis syndrome caused by P-element DNA transposons, in which dysgenic female ovaries often contain few or no germline cells. Those offspring that are produced from dysgenic germlines exhibit high rates of de novo mutation and recombination,...

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PMID: 29294306
DOI: 10.1016/j.ydbio.2017.12.021

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