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Article

Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary.

Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 2011

Eliazer Susan, Shalaby Nevine A, Buszczak Michael

Abstract excerpt

Specialized microenvironments called niches keep stem cells in an undifferentiated and self-renewing state. Dedicated stromal cells form niches by producing a variety of factors that act directly on stem cells. The size and signaling output of niches must be finely tuned to ensure proper tissue homeostasis. Although advances have been made in identifying factors that promote niche cell fate, the mechanisms that...

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Identifiers

PMID: 21482791
DOI: 10.1073/pnas.1015874108
PMCID: PMC3084046

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GSC

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Source receipt: pubmed, retrieved 7 Sept 2026.

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