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4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma.

Toxicology letters - 10 Jan 2013

Chung Chi-Jung, Pu Yeong-Shiau, Shiue Horng-Sheng, Lee Hui-Ling, Lin Pinpin, Yang Hsiu-Yuan, Su Chien-Tien, Hsueh Yu-Mei

Abstract excerpt

Gene polymorphisms of the 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes-cytochrome P450 (CYP) monooxygenase 2A13 (CYP2A13) and UDP-glucuronosyltransferases (UGT)-2B7 could contribute to the levels of NNK-related metabolites in urine, thereby increasing the susceptibility to urothelial carcinoma (UC). Therefore, our study aimed to evaluate the roles of two gene polymorphisms...

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PMID: 23142425
DOI: 10.1016/j.toxlet.2012.11.002

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