Article
Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.
Human molecular genetics - 15 Feb 2015
Matsuda Koichi, Takahashi Atsushi, Middlebrooks Candace D, Obara Wataru, Nasu Yasutomo, Inoue Keiji, Tamura Kenji, Yamasaki Ichiro, Naya Yoshio, Tanikawa Chizu, Cui Ri, Figueroa Jonine D, Silverman Debra T, Rothman Nathaniel, Namiki Mikio, Tomita Yoshihiko, Nishiyama Hiroyuki, Kohri Kenjiro, Deguchi Takashi, Nakagawa Masayuki, Yokoyama Masayoshi, Miki Tsuneharu, Kumon Hiromi, Fujioka Tomoaki, Prokunina-Olsson Ludmila, Kubo Michiaki, Nakamura Yusuke, Shuin Taro
Abstract excerpt
Through genome-wide association analysis and an independent replication study using a total of 1131 bladder cancer cases and 12 558 non-cancer controls of Japanese populations, we identified a susceptibility locus on chromosome 15q24. SNP rs11543198 was associated with bladder cancer risk with odds ratio (OR) of 1.41 and P-value of 4.03 × 10(-9). Subgroup analysis revealed rs11543198 to have a stronger effect in...
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