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Article

AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility.

Archives of toxicology - 1 Jul 2024

Xiao Yanping, Shen Yang, Song Hui, Gao Fang, Mao Zhenguang, Lv Qiang, Qin Chao, Yuan Lin, Wu Dongmei, Chu Haiyan, Wang Meilin, Du Mulong, Zheng Rui, Zhang Zhengdong

Abstract excerpt

Tobacco carcinogens metabolism-related genes (TCMGs) could generate reactive metabolites of tobacco carcinogens, which subsequently contributed to multiple diseases. However, the association between genetic variants in TCMGs and bladder cancer susceptibility remains unclear. In this study, we derived TCMGs from metabolic pathways of polycyclic aromatic hydrocarbons and tobacco-specific nitrosamines, and then...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38662237
DOI: 10.1007/s00204-024-03737-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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