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Article

Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.

Carcinogenesis - 1 Oct 2008

Figueroa Jonine D, Malats Núria, García-Closas Montserrat, Real Francisco X, Silverman Debra, Kogevinas Manolis, Chanock Stephen, Welch Robert, Dosemeci Mustafa, Lan Qing, Tardón Adonina, Serra Consol, Carrato Alfredo, García-Closas Reina, Castaño-Vinyals Gemma, Rothman Nathaniel

Abstract excerpt

Aromatic amines (AAs) and polycyclic aromatic hydrocarbons (PAHs) are carcinogens present in tobacco smoke and functional polymorphisms in NAT2 and GSTM1 metabolizing genes are associated with increased bladder cancer risk. We evaluated whether genetic variation in other candidate metabolizing genes are also associated with risk. Candidates included genes that control the transcription of metabolizing genes [aryl...

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Share to 3-Hydroxysteroid Dehydrogenases
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aryl Hydrocarbon Receptor Nuclear Translocator

Share to Cytochrome P-450 CYP1A1

Share to Cytochrome P-450 CYP1B1

Share to Cytochrome P-450 Enzyme System

Share to Glutathione Transferase

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 18632753
DOI: 10.1093/carcin/bgn163
PMCID: PMC2556968

Genes

ARNT
AHR
AHRR
EPHX1
EPHX2
GSTM1
MPO
NAT2
NQO1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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