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Article

Vps35-dependent recycling of Trem2 regulates microglial function.

Traffic (Copenhagen, Denmark) - 1 Dec 2016

Yin Jie, Liu Xiaocui, He Qing, Zhou Lujun, Yuan Zengqiang, Zhao Siqi

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (Trem2), an immune-modulatory receptor, is preferentially expressed in microglia of central nervous system. Trem2 might be involved in the development of Alzheimer's disease (AD) through regulating the inflammatory responses and phagocytosis of microglia. However, the intracellular trafficking of Trem2 remains unclear. In this study, we showed that Trem2 in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27717139
DOI: 10.1111/tra.12451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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