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Article

Intracellular trafficking of TREM2 is regulated by presenilin 1.

Experimental & molecular medicine - 1 Dec 2017

Zhao Yingjun, Li Xiaoguang, Huang Timothy, Jiang Lu-Lin, Tan Zhenqiu, Zhang Muxian, Cheng Irene Han-Juo, Wang Xin, Bu Guojun, Zhang Yun-Wu, Wang Qi, Xu Huaxi

Abstract excerpt

Genetic mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to a variety of neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia and Parkinson's disease. In the brain, TREM2 is highly expressed on the cell surface of microglia, where it can transduce signals to regulate microglial functions such as phagocytosis. To...

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Share to Immunoprecipitation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29611543
DOI: 10.1038/emm.2017.200
PMCID: PMC5750471

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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