TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

Abstract excerpt

<title>Abstract</title> <p>Triggering receptor expressed on myeloid cell 2 (TREM2) is a surface receptor that, in the central nervous system, is exclusively expressed on microglia. TREM2 variants have been linked to increased risk for neurodegenerative diseases, but the functional effects of microglial TREM2 remain largely unknown. To this end, we investigated TAR-DNA binding protein 43 kDa (TDP-43)-related neuro...

Topics

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• Central Nervous System
• Inflammation biomarkers and pathways
• Microglia
• Myeloid Cells
• Neurodegenerative Diseases
• Receptors, Immunologic
• Regeneration
• Toll-Like Receptors

Identifiers and source

Literature Corpus work

23434e7a-e953-5572-8853-c9e16cec4def

DOI

10.21203/rs.3.rs-133413/v1