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Article

Prevalence of mutations in LEP, LEPR, and MC4R genes in individuals with severe obesity.

Genetics and molecular research : GMR - 19 Aug 2016

Paolini B, Maltese P E, Del Ciondolo I, Tavian D, Missaglia S, Ciuoli C, Zuntini M, Cecchin S, Bertelli M, Pompucci G

Abstract excerpt

Obesity is a major public health concern; despite evidence of high heritability, the genetic causes of obesity remain unclear. In this study, we assessed the presence of mutations in three genes involved in the hypothalamic leptin-melanocortin regulation pathway (leptin, LEP; leptin receptor, LEPR; and melanocortin-4 receptor, MC4R), which is important for energy homeostasis in the body, in a group of patients...

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Share to Body Mass Index
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leptin

Share to Mutation, Missense

Share to Obesity, Morbid

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Share to Receptor, Melanocortin, Type 4

Share to Receptors, Leptin

Source

Identifiers

PMID: 27706562
DOI: 10.4238/gmr.15038718

Genes

LEP
LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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