Article
Novel variants in the MC4R and LEPR genes among severely obese children from the Iberian population.
Annals of human genetics - 1 May 2014
Albuquerque David, Estévez Manuela Núñez, Víbora Pilar Beato, Giralt Plácida Sánchez, Balsera Aránzazu Margallo, Cortés Pedro Gil, López Mercedes Jiménez, Luego Luis Miguel, Gervasini Guillermo, Hernández Sergio Barroso, Arroyo-Díez Javier, Vacas Manuel Arrobas, Nóbrega Clévio, Manco Licínio, Rodríguez-López Raquel
Abstract excerpt
We screened for mutations in the MC4R and LEPR genes and investigated the genotype-phenotype correlation in obese individuals belonging to families with evident hereditary patterns of severe and early-onset obesity among the Iberian population. A total of 202 unrelated and severely obese patients since childhood, were enrolled in the study. Bidirectional sequencing of the MC4R gene was carried out in all...
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