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Article

Melanocortin 4 receptor (MC4R) gene variants in children and adolescents having familial early-onset obesity: genetic and clinical characteristics.

European journal of pediatrics - 1 Sept 2020

Aykut Ayça, Özen Samim, Gökşen Damla, Ata Aysun, Onay Hüseyin, Atik Tahir, Darcan Şükran, Özkinay Ferda

Abstract excerpt

Melanocortin 4 receptor gene plays an important role in food intake, energy balance, and weight control. The autosomal dominantly inherited MC4R variants cause obesity by causing hyperphagia and decreased sense of satiety. Homozygous variants are rarely reported, and they cause earlier/severe obesity. Our objective is to determine the MC4R gene variant frequency in children and adolescents with familial...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

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Source

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Identifiers

PMID: 32185475
DOI: 10.1007/s00431-020-03630-7
PMCID: PMC7223532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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