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Article

Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population.

Obesity (Silver Spring, Md.) - 1 Nov 2012

Rouskas Konstantinos, Meyre David, Stutzmann Fanny, Paletas Konstantinos, Papazoglou Dimitrios, Vatin Vincent, Marchand Marion, Kouvatsi Anastasia, Froguel Philippe

Abstract excerpt

Melanocortin-4 receptor (MC4R) loss-of-function mutations are the commonest genetic cause of human monogenic obesity, so far. The contribution of MC4R coding mutations to severe obesity in the high-obesity prone Greek population has not been investigated to date. We determined the MC4R coding sequence of 510 obese and 469 lean control subjects of Greek origin, and we estimated the prevalence and the penetrance on...

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Source

Identifiers

PMID: 22447289
DOI: 10.1038/oby.2012.77

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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