Article

Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa

2024-01-12

Abstract excerpt

<title>Abstract</title> <p>Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system confer a risk for monogenic forms of obesity. Yet, gain of function variants in the melanocortin-4-receptor (<italic>MC4R</italic>) gene predispose to a lower BMI. In individuals with reduced body weight, we thus expected mutations leading to an enhanced function in the respective genes, like l...

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Literature Corpus work: 5c09eb72-a7a8-5042-b758-bdf5b9f0cb0b
DOI: 10.21203/rs.3.rs-3850003/v1

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