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Article

Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population.

Obesity (Silver Spring, Md.) - 1 Aug 2015

Saeed Sadia, Bonnefond Amélie, Manzoor Jaida, Shabbir Faiza, Ayesha Hina, Philippe Julien, Durand Emmanuelle, Crouch Hutokshi, Sand Olivier, Ali Muhammad, Butt Taeed, Rathore Ahsan W, Falchi Mario, Arslan Muhammad, Froguel Philippe

Abstract excerpt

OBJECTIVE: Single gene mutations leading to severe obesity have so far been identified in 3-5% cases in European populations. However, prevalence of these pathogenic mutations has not systematically been examined in specific consanguineous populations. Here we describe the incidence of obesity-associated mutations through a step-wise sequence analysis, in a cohort of 73 Pakistani children with severe obesity from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

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Source

Identifiers

PMID: 26179253
DOI: 10.1002/oby.21142

Genes

LEP
LEPR
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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