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Article

Genetics of Severe Obesity.

Current diabetes reports - 18 Aug 2018

Fairbrother Una, Kidd Elliot, Malagamuwa Tanya, Walley Andrew

Abstract excerpt

PURPOSE OF REVIEW: This review aims to present current information on genes underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and MC4R. RECENT FINDINGS: There is a substantial amount of evidence that variants in at least ten different genes are the cause of severe monogenic obesity. The majority of these are involved in the leptin-melanocortin signalling pathway. Due to the frequency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

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Source

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Identifiers

PMID: 30121879
DOI: 10.1007/s11892-018-1053-x
PMCID: PMC6105241

Genes

LEP
LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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