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Genetic Insights into Severe Obesity: A Case Study of MC4R Variant Identification and Clinical Implications

28 Apr 2025

Abstract excerpt

Background/Objectives: Severe early-onset obesity is a complex condition shaped by genetic and metabolic influences. The melanocortin 4 receptor (MC4R) gene plays a crucial role in energy balance, and pathogenic variants are associated with monogenic forms of obesity. This study aims to examine the clinical, metabolic, and genetic characteristics of a patient with severe early-onset obesity and his family, to...

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PMID: 40428329
DOI: 10.3390/genes16050508

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