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Article

Six novel mutations in the proopiomelanocortin and melanocortin receptor 4 genes in severely obese adults living in southern Italy.

Clinical chemistry - 1 Aug 2005

Buono Pasqualina, Pasanisi Fabrizio, Nardelli Carmela, Ieno Luigi, Capone Silvana, Liguori Rosario, Finelli Carmine, Oriani Giovannangelo, Contaldo Franco, Sacchetti Lucia

Abstract excerpt

BACKGROUND: The genetic characterization of obese individuals could clarify the molecular mechanisms underlying body weight regulation and lead to targeted therapy. Here we report variants of the proopiomelanocortin (POMC) and melanocortin receptor 4 (MC4R) genes detected in severely obese adults living in southern Italy. METHODS: A total of 196 unrelated nondiabetic severely obese individuals [111 females and 85...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15951321
DOI: 10.1373/clinchem.2005.047886

Genes

POMC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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