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Article

A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor.

Biophysical journal - 4 Oct 2016

Barchad-Avitzur Ofra, Priest Michael F, Dekel Noa, Bezanilla Francisco, Parnas Hanna, Ben-Chaim Yair

Abstract excerpt

G protein-coupled receptors (GPCRs) mediate many signal transduction processes in the body. The discovery that these receptors are voltage-sensitive has changed our understanding of their behavior. The M2 muscarinic acetylcholine receptor (M2R) was found to exhibit depolarization-induced charge movement-associated currents, implying that this prototypical GPCR possesses a voltage sensor. However, the typical...

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Identifiers

PMID: 27705763
DOI: 10.1016/j.bpj.2016.08.035
PMCID: PMC5052511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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