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Article

Voltage-dependent gating in a "voltage sensor-less" ion channel.

PLoS biology - 23 Feb 2010

Kurata Harley T, Rapedius Markus, Kleinman Marc J, Baukrowitz Thomas, Nichols Colin G

Abstract excerpt

The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity. We have identified a remarkable point mutation that confers significant voltage dependence to Kir6.2, a ligand-gated channel that lacks any canonical voltage-sensing domain. Similar to...

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Identifiers

PMID: 20208975
DOI: 10.1371/journal.pbio.1000315
PMCID: PMC2826373

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