Article

Voltage-gating of mechanosensitive PIEZO channels

2017-06-27

Abstract excerpt

<h4>Summary</h4> Mechanosensitive PIEZO ion channels are evolutionarily conserved proteins whose presence is critical for normal physiology in multicellular organisms. Here we show that, in addition to mechanical stimuli, PIEZO channels are also powerfully modulated by voltage and can even switch to a purely voltage gated mode. Mutations that cause human diseases such as Xerocytosis profoundly shift voltage sensi...

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Literature Corpus work: 8f281a7c-c9c8-5aec-8486-7710faa60465
DOI: 10.1101/156489

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