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Article

Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity.

Scientific reports - 21 Jul 2017

Chen I-Shan, Furutani Kazuharu, Kurachi Yoshihisa

Abstract excerpt

Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine. We previously have demonstrated that the regulator of G-protein signaling (RGS) 4 protein discriminates between the voltage-dependent responses of ACh and pilocarpine; however, the...

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Identifiers

PMID: 28733581
DOI: 10.1038/s41598-017-05128-z
PMCID: PMC5522400

Genes

RGS4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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