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Article

The mode of agonist binding to a G protein-coupled receptor switches the effect that voltage changes have on signaling.

Science signaling - 3 Nov 2015

Rinne Andreas, Mobarec Juan Carlos, Mahaut-Smith Martyn, Kolb Peter, Bünemann Moritz

Abstract excerpt

Signaling by many heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) is either enhanced or attenuated by changes in plasma membrane potential. To identify structural correlates of the voltage sensitivity of GPCR signaling, we chose muscarinic acetylcholine receptors (the M1, M3, and M5 isoforms) as a model system. We combined molecular docking analysis with Förster resonance...

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PMID: 26535008
DOI: 10.1126/scisignal.aac7419

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