Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elucidating the origin of HLA-B*73 allelic lineage: Did modern humans benefit by archaic introgression?

Immunogenetics - 1 Jan 2017

Yasukochi Yoshiki, Ohashi Jun

Abstract excerpt

A previous study reported that some of the human leukocyte antigen (HLA) alleles and haplotypes in present-day humans were acquired by admixture with archaic humans; specifically, an exceptionally diverged HLA-B*73 allele was proposed to be transmitted from Denisovans, although the DNA sequence of HLA-B*73 has not been detected in the Denisovan genome. Here, we argue against the hypothesis that HLA-B*73...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black People
Share to Europe
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Human

Share to HLA-B Antigens

Share to Hominidae

Share to Neanderthals

Share to Pan troglodytes

Source

Open in PubMed Open full text

Identifiers

PMID: 27695917
DOI: 10.1007/s00251-016-0952-8
PMCID: PMC5203853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elucidating the origin of HLA-B*73 allelic lineage: Did modern humans benefit by archaic introgression?PMID 27695917Read ↗

The shaping of modern human immune systems by multiregional admixture with archaic humans.Semantic proximity Read ↗

Recent origin of HLA-DRB1 alleles and implications for human evolution.Semantic proximity Read ↗

Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2Semantic proximity Read ↗

The major histocompatibility complex and human evolution.Semantic proximity Read ↗

The HLA-B73 antigen has a most unusual structure that defines a second lineage of HLA-B alleles.Semantic proximity Read ↗

Episodic evolution and turnover of HLA-B in the indigenous human populations of the Americas.Semantic proximity Read ↗

Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors.Semantic proximity Read ↗

Demographic and immune-based selection shifts before and after European contact inferred from 50 ancient and modern exomes from the Northwest Coast of North AmericaSemantic proximity Read ↗

Genetic and phenotypic consequences of introgression between humans and Neanderthals.Semantic proximity Read ↗

New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci.Semantic proximity Read ↗

HLA in anthropology: the enigma of Easter Island.Semantic proximity Read ↗

HLA genetic diversity in Hungarians and Hungarian Gypsies: complementary differentiation patterns and demographic signals revealed by HLA-A, -B and -DRB1 in Central Europe.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.