Article
New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci.
Nature - 28 May 1992
Watkins D I, McAdam S N, Liu X, Strang C R, Milford E L, Levine C G, Garber T L, Dogon A L, Lord C I, Ghim S H
Abstract excerpt
Evidence suggests that the New World was colonized only 11,000-40,000 years ago by Palaeo-Indians. The descendants of these Palaeo-Indians therefore provide a unique opportunity to study the effects of selection on major histocompatibility complex class I genes over a short period. Here we analyse the class I alleles of the Waorani of South America and the Zuni of North America. Four of the Waorani HLA-B alleles...
Topics
- Alleles
- Amino Acid Sequence
- Asian People
- Base Sequence
- Biological Evolution
- Genetic Variation
- HLA-A Antigens
- HLA-B Antigens
- Histocompatibility Antigens Class I
- Humans
- Indians, North American