Recent origin of HLA-DRB1 alleles and implications for human evolution.

doi:10.1038/ng0398-237

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Article

Recent origin of HLA-DRB1 alleles and implications for human evolution.

Nature genetics - 1 Mar 1998

Bergström T F, Josefsson A, Erlich H A, Gyllensten U

Abstract excerpt

The HLA class I and class II loci are the most highly polymorphic coding regions in the human genome. Based on the similarity of the coding sequences of alleles between species, it has been claimed that the HLA polymorphism is ancient and predates the separation of human (Homo) and chimpanzee (Pa...

Topics

Alleles
Animals
Base Sequence
Biological Evolution
Genetic Variation
Genetics, Population
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Introns
Models, Genetic
Molecular Sequence Data
Phylogeny
Polymorphism, Genetic
Primates
Sequence Homology, Nucleic Acid
Time Factors

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