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Article

The major histocompatibility complex and human evolution.

Trends in genetics : TIG - 1 Jan 1990

Klein J, Gutknecht J, Fischer N

Abstract excerpt

Many alleles at the human major histocompatibility complex (HLA) loci diverged before the divergence of humans and great apes from a common ancestor. This fact puts a lower limit on the size of the bottleneck in human evolution: the genus Homo must have been founded by no less than ten and probably by more than 10,000 individuals.

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PMID: 2183415
DOI: 10.1016/0168-9525(90)90042-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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