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Article

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.

PLoS biology - 24 Aug 2010

Kirmaier Andrea, Wu Fan, Newman Ruchi M, Hall Laura R, Morgan Jennifer S, O'Connor Shelby, Marx Preston A, Meythaler Mareike, Goldstein Simoy, Buckler-White Alicia, Kaur Amitinder, Hirsch Vanessa M, Johnson Welkin E

Abstract excerpt

Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed macaques. Cellular assays and phylogenetic comparisons indirectly support a role for TRIM5alpha, the product of the TRIM5 gene, in suppressing interspecies transmission and emergence of...

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Source

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Identifiers

PMID: 20808775
DOI: 10.1371/journal.pbio.1000462
PMCID: PMC2927514

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.PMID 20808775Read ↗

Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles.Semantic proximity Read ↗

TRIM5α restriction affects clinical outcome and disease progression in simian immunodeficiency virus-infected rhesus macaques.Semantic proximity Read ↗

TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys.Semantic proximity Read ↗

Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities.Semantic proximity Read ↗

TRIM5 alpha drives SIVsmm evolution in rhesus macaques.Semantic proximity Read ↗

Distinct Evolutionary Pressures Underlie Diversity in Simian Immunodeficiency Virus and Human Immunodeficiency Virus LineagesSemantic proximity Read ↗

APOBEC3F Constitutes a Barrier to Successful Cross-Species Transmission of Simian Immunodeficiency Virus SIVsmm to Humans.Semantic proximity Read ↗

TRIM5α Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains.Semantic proximity Read ↗

Modern-day SIV viral diversity generated by extensive recombination and cross-species transmission.Semantic proximity Read ↗

Modern-Day SIV Viral Diversity Generated by Extensive Recombination and Cross-Species TransmissionSemantic proximity Read ↗

Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstm.Semantic proximity Read ↗

Evolution of the uniquely adaptable lentiviral envelope in a natural reservoir host.Semantic proximity Read ↗

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