Article
Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.
American journal of respiratory and critical care medicine - 15 Mar 2017
Boueiz Adel, Lutz Sharon M, Cho Michael H, Hersh Craig P, Bowler Russell P, Washko George R, Halper-Stromberg Eitan, Bakke Per, Gulsvik Amund, Laird Nan M, Beaty Terri H, Coxson Harvey O, Crapo James D, Silverman Edwin K, Castaldi Peter J, DeMeo Dawn L
Abstract excerpt
RATIONALE: Emphysema has considerable variability in the severity and distribution of parenchymal destruction throughout the lungs. Upper lobe-predominant emphysema has emerged as an important predictor of response to lung volume reduction surgery. Yet, aside from alpha-1 antitrypsin deficiency, the genetic determinants of emphysema distribution remain largely unknown. OBJECTIVES: To identify the genetic...
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