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Article

Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.

Respiratory research - 16 Mar 2010

Cho Michael H, Washko George R, Hoffmann Thomas J, Criner Gerard J, Hoffman Eric A, Martinez Fernando J, Laird Nan, Reilly John J, Silverman Edwin K

Abstract excerpt

BACKGROUND: Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity. METHODS: We selected 31 phenotypic variables and 12 SNPs from five candidate genes in 308 subjects in the National Emphysema Treatment Trial (NETT)...

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PMID: 20233420
DOI: 10.1186/1465-9921-11-30
PMCID: PMC2850331

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TGFB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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