Article

Integrative genomics analysis identifies <i>ACVR1B</i> as a candidate causal gene of emphysema distribution in non-alpha 1-antitrypsin deficient smokers

2017-09-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Several genetic risk loci associated with emphysema apico-basal distribution (EABD) have been identified through genome-wide association studies (GWAS), but the biological functions of these variants are unknown. To characterize gene regulatory functions of EABD-associated variants, we integrated EABD GWAS results with 1) a multi-tissue panel of expression quantitative trait...

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Literature Corpus work: 0fadac99-22a5-5899-b4df-6be8fad38eb8
DOI: 10.1101/189100

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