Article
National Emphysema Treatment Trial state of the art: genetics of emphysema.
Proceedings of the American Thoracic Society - 1 May 2008
Hersh Craig P, DeMeo Dawn L, Silverman Edwin K
Abstract excerpt
Although a hereditary contribution to emphysema has been long suspected, severe alpha1-antitrypsin deficiency remains the only conclusively proven genetic risk factor for chronic obstructive pulmonary disease (COPD). Recently, genome-wide linkage analysis has led to the identification of two promising candidate genes for COPD: TGFB1 and SERPINE2. Like multiple other COPD candidate gene associations, even these...
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