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Article

Genetic determinants of emphysema distribution in the national emphysema treatment trial.

American journal of respiratory and critical care medicine - 1 Jul 2007

DeMeo Dawn L, Hersh Craig P, Hoffman Eric A, Litonjua Augusto A, Lazarus Ross, Sparrow David, Benditt Joshua O, Criner Gerard, Make Barry, Martinez Fernando J, Scanlon Paul D, Sciurba Frank C, Utz James P, Reilly John J, Silverman Edwin K

Abstract excerpt

RATIONALE: Computed tomography (CT) scanning of the lung may reduce phenotypic heterogeneity in defining subjects with chronic obstructive pulmonary disease (COPD), and allow identification of genetic determinants of emphysema severity and distribution. OBJECTIVES: We sought to identify genes associated with CT scan distribution of emphysema in individuals without alpha1-antitrypsin deficiency but with severe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17363767
DOI: 10.1164/rccm.200612-1797OC
PMCID: PMC2049064

Genes

EPHX1
GSTP1
MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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