Article
Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
American journal of respiratory and critical care medicine - 15 Feb 2014
Manichaikul Ani, Hoffman Eric A, Smolonska Joanna, Gao Wei, Cho Michael H, Baumhauer Heather, Budoff Matthew, Austin John H M, Washko George R, Carr J Jeffrey, Kaufman Joel D, Pottinger Tess, Powell Charles A, Wijmenga Cisca, Zanen Pieter, Groen Harry J M, Postma Dirkje S, Wanner Adam, Rouhani Farshid N, Brantly Mark L, Powell Rhea, Smith Benjamin M, Rabinowitz Dan, Raffel Leslie J, Hinckley Stukovsky Karen D, Crapo James D, Beaty Terri H, Hokanson John E, Silverman Edwin K, Dupuis Josée, O'Connor George T, Boezen H Marike, Rich Stephen S, Barr R Graham
Abstract excerpt
RATIONALE: Pulmonary emphysema overlaps partially with spirometrically defined chronic obstructive pulmonary disease and is heritable, with moderately high familial clustering. OBJECTIVES: To complete a genome-wide association study (GWAS) for the percentage of emphysema-like lung on computed tomography in the Multi-Ethnic Study of Atherosclerosis (MESA) Lung/SNP Health Association Resource (SHARe) Study, a...
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