Article
Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells.
Nature chemistry - 1 Oct 2016
Kiyonaka Shigeki, Kubota Ryou, Michibata Yukiko, Sakakura Masayoshi, Takahashi Hideo, Numata Tomohiro, Inoue Ryuji, Yuzaki Michisuke, Hamachi Itaru
Abstract excerpt
The controlled activation of proteins in living cells is an important goal in protein-design research, but to introduce an artificial activation switch into membrane proteins through rational design is a significant challenge because of the structural and functional complexity of such proteins. Here we report the allosteric activation of two types of membrane-bound neurotransmitter receptors, the ion-channel type...
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