Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conformational intermediate in glutamate receptor activation.

Neuron - 7 Aug 2013

Lau Albert Y, Salazar Héctor, Blachowicz Lydia, Ghisi Valentina, Plested Andrew J R, Roux Benoît

Abstract excerpt

Ionotropic glutamate receptors (iGluRs) transduce the chemical signal of neurotransmitter release into membrane depolarization at excitatory synapses in the brain. The opening of the transmembrane ion channel of these ligand-gated receptors is driven by conformational transitions that are induced by the association of glutamate molecules to the ligand-binding domains (LBDs). Here, we describe the crystal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biophysical Phenomena
Share to Electric Stimulation
Share to Excitatory Amino Acid Antagonists

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Molecular Conformation

Share to Quinoxalines

Share to Receptors, Glutamate

Share to Uncoupling Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 23931998
DOI: 10.1016/j.neuron.2013.06.003
PMCID: PMC3814226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conformational intermediate in glutamate receptor activation.PMID 23931998Read ↗

Mechanism of glutamate receptor desensitization.Semantic proximity Read ↗

Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation.Semantic proximity Read ↗

Measurements of the Timescale and Conformational Space of AMPA Receptor Desensitization.Semantic proximity Read ↗

Emerging models of glutamate receptor ion channel structure and function.Semantic proximity Read ↗

Domain organization and function in GluK2 subtype kainate receptors.Semantic proximity Read ↗

Cross-subunit Interactions that Stabilize Open States Mediate Gating in NMDA ReceptorsSemantic proximity Read ↗

Steered Molecular Dynamics Simulations Predict Conformational Stability of Glutamate Receptors.Semantic proximity Read ↗

Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.Semantic proximity Read ↗

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors.Semantic proximity Read ↗

Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors.Semantic proximity Read ↗

Arrangement of subunits in functional NMDA receptors.Semantic proximity Read ↗

Structures of partially occupied hetero-tetramers provide insight into kainate receptor activation and desensitization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.