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Article

Controlling Engineered P2X Receptors with Light.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Atkinson Benjamin N, Chudasama Vijay, Browne Liam E

Abstract excerpt

This chapter details methods to express and modify ATP-gated P2X receptor channels so that they can be controlled using light. Following expression in cells, a photoswitchable tool compound can be used to covalently modify mutant P2X receptors, as previously demonstrated for homomeric P2X2 and P2X3 receptors, and heteromeric P2X2/3 receptors. Engineered P2X receptors can be rapidly and reversibly opened and...

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PMID: 31646498
DOI: 10.1007/978-1-4939-9717-6_22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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