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Article

Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology.

eLife - 28 Oct 2020

Lemoine Damien, Mondoloni Sarah, Tange Jérome, Lambolez Bertrand, Faure Philippe, Taly Antoine, Tricoire Ludovic, Mourot Alexandre

Abstract excerpt

Glutamate delta (GluD) receptors belong to the ionotropic glutamate receptor family, yet they don't bind glutamate and are considered orphan. Progress in defining the ion channel function of GluDs in neurons has been hindered by a lack of pharmacological tools. Here, we used a chemo-genetic approach to engineer specific and photo-reversible pharmacology in GluD2 receptor. We incorporated a cysteine mutation in...

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Identifiers

PMID: 33112237
DOI: 10.7554/eLife.59026
PMCID: PMC7679134

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