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Article

Engineering a GPCR-ligand pair that simulates the activation of D(2L) by Dopamine.

ACS chemical neuroscience - 20 Jan 2010

Tschammer Nuska, Dörfler Miriam, Hübner Harald, Gmeiner Peter

Abstract excerpt

In the past decade, engineered G-protein-coupled receptors activated solely by synthetic ligands (RASSLs) have been implemented as a new means to study neurotransmission, which is controlled by G-protein-coupled receptors in vitro and in vivo. In this study, we report an engineered dopamine receptor D(2L) F390(6.52)W, which is the first identified RASSL for the dopamine receptor family. The mutant receptor is...

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Identifiers

PMID: 22778805
DOI: 10.1021/cn900001b
PMCID: PMC3368624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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