Article
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors.
Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013
Doumazane Etienne, Scholler Pauline, Fabre Ludovic, Zwier Jurriaan M, Trinquet Eric, Pin Jean-Philippe, Rondard Philippe
Abstract excerpt
In multimeric cell-surface receptors, the conformational changes of the extracellular ligand-binding domains (ECDs) associated with receptor activation remain largely unknown. This is the case for the dimeric metabotropic glutamate receptors even though a number of ECD structures have been solved. Here, using an innovative approach based on cell-surface labeling and FRET, we demonstrate that a reorientation of...
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