Article
Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation.
Biophysical journal - 23 Feb 2016
Baranovic Jelena, Chebli Miriam, Salazar Hector, Carbone Anna L, Faelber Katja, Lau Albert Y, Daumke Oliver, Plested Andrew J R
Abstract excerpt
Ionotropic glutamate receptors are postsynaptic tetrameric ligand-gated channels whose activity mediates fast excitatory transmission. Glutamate binding to clamshell-shaped ligand binding domains (LBDs) triggers opening of the integral ion channel, but how the four LBDs orchestrate receptor activation is unknown. Here, we present a high-resolution x-ray crystal structure displaying two tetrameric LBD arrangements...
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